Annals of Indian Psychiatry

: 2019  |  Volume : 3  |  Issue : 2  |  Page : 92--96

Testosterone and schizophrenia: A clinical review

Pragya Lodha1, Sagar Karia2 
1 Clinical Psychologist, Desousa Foundation and Minds Foundation, Mumbai, Maharashtra, India
2 Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Sagar Karia
Department of Psychiatry, 2nd Floor, New OPD Building, Lokmanya Tilak Municipal Medical College and GH, Sion, Mumbai - 400 022, Maharashtra

The relationship between testosterone and psychiatric disorders has been a long-standing one. The sex difference in schizophrenia has triggered to better understand the role that testosterone plays in the unfolding and clinical presentation of this psychotic disorder. DHEA and testosterone are found to influence dopaminergic, glutamatergic and GABAergic neurotransmission systems that are believed to play a role in the pathophysiology of schizophrenia. The onset of schizophrenia in males, most frequently encountered during adolescence, is also characterized by an increase in testosterone levels. Some studies have also observed lower testosterone levels in adult males with schizophrenia (or psychosis) compared to healthy controls.

How to cite this article:
Lodha P, Karia S. Testosterone and schizophrenia: A clinical review.Ann Indian Psychiatry 2019;3:92-96

How to cite this URL:
Lodha P, Karia S. Testosterone and schizophrenia: A clinical review. Ann Indian Psychiatry [serial online] 2019 [cited 2020 Sep 29 ];3:92-96
Available from:;year=2019;volume=3;issue=2;spage=92;epage=96;aulast=Lodha;type=0