Annals of Indian Psychiatry

CASE REPORT
Year
: 2021  |  Volume : 5  |  Issue : 1  |  Page : 79--82

Leukopenia Related to Haloperidol in a Case of Chronic Untreated Schizophrenia


Hrishikesh B Nachane1, Gaurav E Pawar2 
1 Department of Psychiatry, TNMC and BYL Nair Ch. Hospital, Mumbai, Maharashtra, India
2 Department of Psychiatry, Grant Government Medical College and JJ Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Hrishikesh B Nachane
63, Sharmishtha, Tarangan, Thane – West, Thane - 400 606, Maharashtra
India

Haloperidol is a commonly prescribed first-generation antipsychotic drug in psychiatric practice. It is usually well tolerated and presents with few side effects such as sedation, antiparkinsonian features, and hypotension. Few cases have been reported on leukopenia with haloperidol, none from India. We present a case where a patient with untreated schizophrenia for 9 years developed leukopenia (total leukocyte count [TLC] = 2800 cells/mm3) at 20 mg of oral haloperidol, in our inpatient setting. He chiefly presented with fever. The causality of adverse drug reaction (ADR) was attributed to haloperidol and using the Naranjo algorithm, the score recorded was 8, suggesting probable causal association. Hartwig's Severity Assessment Scale showed the severity of the ADR to be Level 4 (moderate severity). There was prompt reversal after drug discontinuation (TLC = 7000 cells/mm3 at discharge). Risk factors, possible mechanisms, and role of monitoring are discussed.


How to cite this article:
Nachane HB, Pawar GE. Leukopenia Related to Haloperidol in a Case of Chronic Untreated Schizophrenia.Ann Indian Psychiatry 2021;5:79-82


How to cite this URL:
Nachane HB, Pawar GE. Leukopenia Related to Haloperidol in a Case of Chronic Untreated Schizophrenia. Ann Indian Psychiatry [serial online] 2021 [cited 2021 Sep 24 ];5:79-82
Available from: https://www.anip.co.in/article.asp?issn=2588-8358;year=2021;volume=5;issue=1;spage=79;epage=82;aulast=Nachane;type=0